Glia development
20 important questions on Glia development
Where do OPC come from in the neural tube?
What is the specific importance of SHH in oligodendrocyte formation? day 9-11
What is the second source of OPC from neural tube?
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How are transgenic mice generated?
- prom/enhancer site of GOI linked to another gene (with CRE conditional knockout)
- full knockout
- inducible conditional knockout (tamoxifen)
How does Conditional knockout work?
What is the functional significance of inducible conditional knockouts?
How do people study gene expression in embryo?
Can all glia cell type repopulate brain regions even if a certain populate is absent?
How does NGN2 induce motor neuron or oligodendrocyte formation?
What is the function of the Notch?
How do JAK-STAT and cytokines induce glia fate?
What is an important receptor that induce gliogenesis after neurogenesis?
What is the role of Sox9 in gliogenesis?
What is the role of IA and IB?
Which factors and receptor are most implicated in gioneogenesis? see slide
- Sox9
- NFIA
- NFIB
- Notch --> HES
What is the main difference in gene expression between mice and chic?
Chick: OPC when Olig2 and Nkx2.2 overlap
What is the difference between pre-oligo and mature?
What is the specific cell for PLP?
How did the Science 2013 show that WM and GM oligodendrocytes have intrinsically different maturation capacity?
also, mature is more parallel compared to ramified for progenitors.
What to remember from oligodendrocytes of both Science papers?
The question on the page originate from the summary of the following study material:
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