L1 Types and classification of neurons in the NS
7 important questions on L1 Types and classification of neurons in the NS
How can neurons be classified?
But not every neuron is the same.
Basic features commonly used for neuronal classification:
- morphological features (studied by filling neuron with biocytin)
- Biochemical markers expression
- active and passive electrical characteristics
What are the three major compartments of a neuron?
What does bouton distribution reveal?
Neurons can establish 1000s of boutons in a layer specific distribution
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Some axonal projection patterns are:
- Total axonal length (micrometer)
- Number of branching points (n)
- Number of endings (n)
- Branching pattern (Sholl analysis)
- Total No. Of boutons (n)
- Bouton density (n/100 micrometer)
- Layer specific bouton distribution
For which type of neuron classification is Biochemical markers specifically used?
(excitatory neurons typically express layer (i.e. Laminae) specific proteins)
Three passive intrinsic electrical characteristics of neurons are?
Membrane resistance
membrane time constant
What are some active electrical characteristics of neurons?
Rate of adaption upon sustained current injection
Membrane potential at which action potential is generated
Amplitude of sub threshold responses (e.g. After hyperpolarization)
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