L6 Anatomical basis of synaptic plasticity
9 important questions on L6 Anatomical basis of synaptic plasticity
Which of the following about axonal sprouting is/are false?
1. It is the predominant mechanism of structural plasticity in the developing brain
2. It ensures short- and long-range connectivity for functional maturation of the nervous system
3. The dynamics of axonal sprouting determines rate of divergence and convergence of input
4. It is observed only in neocortical neurons
5. It obeys the 'critical window of plasticity'
4
True:
1, 2, 3, 5
Which of the following about synaptogenesis through dendritic branching is/are false?
1. Dendritic branching often accompanies axonal sprouting, especially during development
2. Synaptogenesis includes not only establishing new synapses but also spine motility, structural reorganization, shape and form change
3. Synaptogenesis is neuronal activity dependent during early embryonic development.
4. Activity independent synaptogenesis during adulthood is preferentially observed in excitatory neurons
5. Synaptogenesis determine the number of synapses a given neuron would make with its pre- and post-synaptic partners
3, 4
True:
1, 2, 5
In the ........ Nervous system, ........... Increases while axonal convergence is reduced.
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Which of the following is not a basic structural component of an axonal bouton?
1. Synaptic vesicles
2. Adhesion molecules
3. Ligand gated receptors
4. Voltage gated receptors
5. PSD (postsynaptic density)
5. PSD
Structural component of axonal bouton:
1. Synaptic vesicles
2. Adhesion molecules
3. Ligand gated receptors
4. Voltage gated receptors
Which of the following is/are involved in regulation of the spine morphology?
1. NMDA receptor signaling
2. AMPA receptor signaling
3. Actin polymerisation
4. Synaptic protein assembly
5. Synaptic protein degradation
1. NMDA receptor signaling
2. AMPA receptor signaling
3. Actin polymerisation
4. Synaptic protein assembly
5. Synaptic protein degradation
Why is synaptic competition required?
Alpha-bungarotoxin bind to the alpha subunit of nicotinic acetylcholine receptors in vertebrate skeletal muscles
Locally blocking synaptic transmission at one axon's synaptic site leads to synaptic elimination while the other unblocked inputs are maintained.
Blocking synaptic transmission throughout the target postsynaptic target does not result in synaptic loss !
Suggesting that synaptic elimination requires postsynaptic activity and competition
Do newly formed spines make synapses during maturation?
How persistent is the effect (spine formation resulting from task-based learning)?
And how specific is the effect ?
And does retraining generate more spines?
spine elimination first observed 2 days after training
effects are specific to the contralateral motor cortex
In fact spine survival persists for months.
Retraining the same task does not improve the succes rate, nor does it affect spine formation and elimination
However retraining with a different task does stimulate spine formation and elimination
Structural changes associated with spine dynamics (as they relate to LTP)
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