Depression and bipolar disorder - Anti-depressants
9 important questions on Depression and bipolar disorder - Anti-depressants
Which types of drugs do we have for depression?
- MAOI (prevents breakdown)
- TCA (not selective inhibitors of re-uptake)
- SSRI (selective)
How do Tricyclic antidepressants work?
One more selective for one then the other.
What is typical about the TCA's and SSRI?
Autoreceptors do their job 5HT1D.
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What is the transporter called where the working of the SSRIs is based on? And what is the effect?
They bind to this
Preventing degradation + reuptake
What are adverse effects of SSRIs?
Sexual side-effects
Suicidal thinking
TCAs are not selective. Which receptors do they target more?
- Histamine => drowsiness
- Acetylcholine mus =>.
What are chronic effects of anti-depressants?
- SSRI: Desensitize inhibitory autoreceptors (A, D)
- TCA and ECT: sensitize 5HT1A, less expression of 5HT2A
- Effect post-receptor mechanims => G-coupled proteins
How does Ketamine work?
NMDA antagonist => AMPA => mTOR => protein translation => synaptic plasticity.
What are the mechanisms of actions of lithium?
- Mimic Na+
- Blocks the PI (PIP2, InsP3/DAG etc) pathway
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