Epilepsy - Pharmacology
4 important questions on Epilepsy - Pharmacology
What type of drugs are there against epilepsy (4)?
Na+ is going into the neuron => actiepotential
Ca+ for the neurotransmitter exocytosis.
Inhibition of glutamate is less likely to be used in the clinic.
Name different GABA mediated neural inhibitiors.
Inhibit GABA re-uptake: Tiagabine
Besides the GABA, calcium, natrium and glutamate orientated drugs there are also other ones. Which ones? (4)
- Carbonic Anhydrase Inhibitors => make neurons more hyperpolarised so that a neuron is less likely to depolarize
- Hormones: progesteron
- Cannabidiol.(CBD): use for Dravett syndrome works on a Na channel
- Ketogenic diet: low carbohydrate => you use proteins instead of carbohydrates
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How do carbonic anhydrase inhibition work?
Lower seizure treshold
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