ADHD in adulthood

18 important questions on ADHD in adulthood

Adult presentation of ADHD: pharmocalogical treatment

  • Stimulants
    - first choice
    - releases norepinephrine and dopamine
    - methylphenidate (ritalin, concerta, equasym), amphetamine (Adderall)
    - 30% does not respond or are able to tolerate the stimulants
  • non-stimulants
    - antidepressants
    - antihypertensive agents
    - etc.
  • compliance better in adults than in children, but discontinuation due to:
    - disorginazation
    - difficulty with persistence
    - negative and uninformed media
    - fears over dependency
    - mistaking the treatment as the cause of stigma or disorder
    - lack of knowledge on long-term effects

Adult presentation of ADHD: non-pharmocalogical treatment

  • counseling
  • education
  • psychotherapy
  • skills training programs
  • cognitive training programs
  • coaching


But, are time consuming and have small effects

Adult presentation of ADHD: Attention

  • is not a unitary entity
  • refers to a broad range of cognitive and behavioural processes
  • is a fundamental function of other cognitive abilities such as speaking, memory, orientation, problem solving
  • is crucial for internal planning
  • is crucial for external control of behaviour
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Adult presentation of ADHD: multi-dimensional models of attention

  • alertness
  • vigilance/sustained attention
  • selective attention
  • divided attention
  • strategy/flexibility


sustained attention deficit is the most prominent distubance of attention in ADHD
it enables the subject to direct attention for a long and unbroken period of time

Adult presentation of ADHD: continious performance test (CPT)

  • adults and children are impaired in:
    - commission errors
    - omission errors
    - reaction time
    - variability of reaction time
  • reaction time decreases with time in healthy individuals, but there is a greater decrease in individuals with ADHD
  • A SUSTAINED ATTENTION DEFICIT IN ADHD CANNOT BE CONCLUDED IN STUDIES

Adult presentation of ADHD: vigilance

  • ability to maintain attention over a prolonged period during which infrequent response-demanding events occur
  • individuals with ADHD have an impairment of vigilance compared to healthy individuals, but the slope is the same.
  • no evidence of a sustained attention deficit in children and adults with ADHD
  • on methylphenidate improves omission errors in CPT compared to not using methylphenidate

Adult presentation of ADHD: Alertness

  • tonic alertness:
    - refers to a relatively stable level of attention which changes slowly according to diurnal (during the day) physiological variations of the organism
  • phasic alertness
    - the ability to enhance the activation level following a stimilus of high priority


Is unimpaired in individuals with ADHD

Adult presentation of ADHD: selective attention

  • the ability to focus attention in the face of a distraction
  • selective attention matches with the term concentration

Adult presentation of ADHD: divided attention

  • divided attention is required to respond simultaneously to multiple tasks or multiple task demands

Adult presentation of ADHD: flexibility

the ability to shift the focus of attention in order to control which information from competing sources will be selectively processed

Adult presentation of ADHD: Methylphenidate

improvement on:
  • vigilance
  • selective attention
  • divided attention (unimpaired)
  • flexibility

Adult presentation of ADHD: executive functions

consists of:
  • problem solving
  • planning
  • flexibility
  • abstract thinking
  • concept formation
  • etc. 

Adult presentation of ADHD: problem solving

  • process to attain a goal
  • no immediate apparent approach to solve the problem
  • to attain goal, obstacles have to be surmounted
  • distinction between open en closed problems

Adult presentation of ADHD: Closed problems

  • both initial state and goal state clearly defined.
  • goal state can only be achieved by a certain solution
  • actions and rules are known
  • requires inimpaired convergent thinking
  • transformation tasks (Tower of hanoi/london)


Improvement on MPH

Adult presentation of ADHD: open problems

  • initial state or goal state not defined
  • requires divergent thinking (fluent and original thinking process)
  • verbal and figural fluency tasks


No effect MPH (most real world problems are open problems)

adults with ADHD suffer from
  • impaired social and sexual relationships
  • occupational problems
  • impaired leisure functioning
  • problem in financial matters

Adult presentation of ADHD: Memory

  • prospective memory

remembering to remember. To perform actions in the feature

planning (executive functions) -> retention (retrospective memory) -> self-initiation (prospective remembering) -> execution (executive functions)

Planning deficit in adults with ADHD

Adult presentation of ADHD: Neuropsychological markers

  • evidence for impairment in numerous functions
  • no significant or conclusive results


regularily found impairments
  • vigilance
  • inhibition
  • working memory

Adult presentation of ADHD: Conclusion

  • convincing evidence of cognitive dysfunction
  • no reliable test profile
  • unique profiles in neuropsychological functioning in individuals
  • patients differ from healthy individuals, but there is no distinctive marker

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