Synaptic Transmission - Diseases That Affect the Presynaptic Terminal

4 important questions on Synaptic Transmission - Diseases That Affect the Presynaptic Terminal

Explain the condition of Lamber-Eaton myasthenic syndrome.

The quanta of neurotransmitter (ACh) is reduced in an EPP, which causes muscle weakness.
Anitbodies which bind to Ca2+ channels prevent Ca2+ to release ACh.

Explain congenital myasthenic syndrome.

A condition in which the number of synaptic vesicles available for fusion is reduced. This could be the effect of impaired endocytosis or reduced supply from the cell body. It's a genetic disorder.

What is familial infantile myasthenia?

A condition in which the individual quanta of the synaptic vesicles is reduced (less ACh in each vesicle).
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What is a difference between botulism and tetanus?

- Botulism targets motor neurons, whereas tetanus targets interneurons.-
- Botulism causes paralysis and tetanus causes hyperexcitation (cramps)

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