MENTAL HEALTH - PHARM

9 important questions on MENTAL HEALTH - PHARM

NEUROTRANSMITTER - Dopamine (DA)

actions:
-fine muscle movement
-integration of emotions and thoughts
-decision making
-stimulates hypothalamus to release hormones (sex, thyroid, adrenal) 

decreased= parkinson's dz and depression (SLOW) (DDD= dopamine, decreased, depression)
increased= Schizophrenia and Mania (FAST) (increased sensory)

NEUROTRANSMITTER - GABA (y-aminobutyric acid)

Actions:
-reduces aggression, excitation and anxiety
-anticonvulsant and muscle relaxing properties
-May impair cognition and psychomotor fxning

decreased= anxiety d/o's, schizophrenia, mania, huntington's dz
increased= reduction of anxiety  

**opposite of normal, decreased increases, increased decreases

Antidepressants - SSRIs (Selective Serotonin Reuptake Inhibitors)

-Blocks reuptake and degradation of serotonin
-Ex: Fluoxetine (prozac), sertraline (Zoloft), citalopram (celexa), escitalopram (Lexapro), Fluvoxamine (Luvox).
-Paroxetine (Paxil) *d/t anticholinergic effects, be careful in pts with narrow angle glaucoma ( can worse and leave them blind). 
-SE's: N/V, low libido
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Antidepressants - SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)

-Increase serotonin and NE
-Ex: Venlafaxine (effexor) - can cause HTN, Desvenlafexine (pristiq), Duloxetine (cymbalta - tx of GAD, depression and diabetic peripheral neuropathy).

Antidepressants - SNDIs (Serotonin-Norepinephrine DisInhibitors)

-increase serotonin and norepinephrine
-Mirtazapine (Remeron): antianxiety and antidepressant (SEs: sedation and weight gain, minimal sexual dysfunction and nausea)

Antidepressants - Monoamine Oxidase Inhibitors (MAOIs)

-Monoamine = NT
-MAO = enzyme that destroys NTs
-Ex: Isocarboxazid (Marplan), Phenelzine (Nardil), tranylcyromine (parnate), selegiline (EMSAM). 
-Inhibits MAO which increases monoamines
-SE's: HTN crisis caused by ingestion of aged cheese, pickled or smoked fish and wine with the MAOI- can all cause life threatening vasoconstriction
-when on MAOI, tyramine is not broken down by MAO so the levels rise causing HTN crisis.
-Toxicity w/ oral decongestants and other antidepressants

Antipsychotic Drugs - FIRST Generation

-AKA: conventional antipsychotics, typical, standard: agonists for D2 receptors for dopamine (block attachment of dopamine to receptor) (takes place of dopamine)
-Ex: Chlorpromazine (thorazine), Thioridazine (Mellarill)
-useful in tx of "positive" schizophrenia s/sx - paranoid, grandiose ideas, hallucinations
-SE's: parkinsonism, akinesia, akathesia(restlessness), dyskiesia(involuntary mvmnts), tardive dyskinesia, amenorrhea, galactorrhea, wt gain (more than 100 pounds), and gynecomastia in men.

Antipsychotic drugs - SECOND Generation

-AKA: atypical antipsychotics: dopamine and serotonin antagonists (blockers)
-EX: clozapine (clozaril - at risk for myocarditis), Risperidone (Risperdal), quetepine (seroquel)
-use in tx of positive AND negative s/sx of schizophrenia, less extrapyramidal SE's
-SE's: gynecomastia, galactorrhea, amenorrhea, low libido 
- Agranulocytosis: convulsions, suppress bone marrow, decreased WBC count
- Metabolic syndrome: increase in wt gain, BS, and trigylcerides), highest rsk with Clozapine and olanzapine, less risk of metabolic syndrome: aripiprazole, ziprasidone.
-Aripiprazole (Abilify): dopamine system stabilizer - SE's - insomnia and akathisia (restlessness).

Alzheimer's disease tx

Acetylcholine: plays a role in the formation of memory, a lower level = less memory.
- this dz is thought to be d/t dysfxn in neurons that secret acetylcholine, tx is aimed at preventing the destruction of these neurons
-Anticholinesterase drugs: tacrine (cogne, donepezil (aricept), galantamine (razadyne), rivastigmine (exelon). 
-Noncompetitive N-methyl-D-asparate receptor: memantine (Namenda) - tx of mod-severe alz's dz

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