Cancer screening

14 important questions on Cancer screening

What is your risk to get CRC?

General population  -  4%

1x first degree relative  -  6%
and 1x second degree relative - 8%
etc

What is the epidemiology of CRC

  • 5-year survival CRC
    • without metastasis 93%
    • positive lymphonedes 38%
    • liver metastasis 8%
  • At diagnosis 40% already has metastasis

What is Fecal immunochemical testing (FIT)

  • Can identify as little as 0.3 ml of daily blood in the stool
  • Is less sensitive for occult blood from the stomach and upper small intestine
  • Thus the FIT test is much more specific for bleeding from the colon or lower gastrointestinal tract than alternatives
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What are problems and confounders of the FIT test?

  • Hemoglobin in faeces disintegrates, so the longer you store faeces and at higher temperatures, the less hemoglobin is measured
  • The population screening will start with a cut-off value of 88 ng/ml. The theoretical expectation is that approximately 6.5% will be referred for a colonoscopy
  • Other colon diseases can also give a positive test (IBD, Hemorrhoids)
  • Quality of endoscopist and equipment
  • A large part of the population will not participate

What are the ROC curves

ROC curves for detecting patients with advanced colorectal neoplasia stratified by anatomical subsite, using a quantitative immunochemical FOBT

  • In an ROC curve, the true positive rate is plotted in function of the false positive rate for different positivity thresholds of a quantitative test

What are some limitations for the screening (of CRC)

  • May be a challenge logically
  • Healthcare must be geared to it
  • The interval between screening test must be adequate

Two types of endoscopic treatment

  • Pedenculated polyps
  • sessile or flat polyps

What are the treatments of CRC

  • Endoscopic treatment (stage 0-2)
    • Polypectomy by electric snare coagulation
    • Endoscopic mucosal resection/dissection
  • Surgical treatment (stage 3-4)
    • Sigmoidectomy
    • Hemi-colectomy (R or L)
    • Subtotal colectomy
    • Trans anal total mesolectal excision
    • Proctectomy (with abdominal stoma)
    • Hemi-hepatectomy (metastasis)
  • Surgical techniques
    • Laparoscopy and resection
    • Open Laparotomy and resection
    • Trans anal resection

What is an oncological health care path?

An oncological health care path is a logically coherent whole of individual car processes that a patient goes through

What is the health car path of CRC what is in it

  • Guidance and information regarding bed news conversation
  • Prepare medical / nursing file
  • Screening
  • Nutritional and physical status
  • Geriatrics (in older patients)
  • Need for psychosocial support
  • If necessary, referral to other care providers
  • Discuss Research
  • Planning of the operation
  • Sign up for multi disciplinary meeting to discuss the best treatment

Who is present at the multidisciplinary consultation

  • Surgeon
    • discuss PA and staging results
    • discuss treatment plan, risks, complications
  • Gastroenterologist
  • Internist / oncologist
    • in case of chemotherapy or radiotherapy
  • Radiologist
  • Radiotherapist
    • in case of chemotherapy or radiotherapy
  • Pathologist
  • Geriatrician
  • Ostomy nurse
  • Research nurse
  • Nurse specialist


  • Anesthesiologist
    • preoperative screening
    • medication check
  • Intake (stoma) nurse
    • information health care track and recovery
    • if necessary information on stoma
    • nursing affairs
    • discussing distress thermometer

Where is looked at when screening for psychosocial care

  • Practical
  • Family/social
  • Emotional
  • Religious / spiritual
  • Physically
  • Fatigue
  • Other problems


Questionnaire
  • Distress thermometer
  • CIT (checklist individual tension)

Who is present at the consultation of psychosocial care

  • Nurse specialist / consultant
  • Psychologist
  • Social worker
  • Physiotherapist
  • Dietitian

What are the appointments after dismission?

  • 2 week after discharge
    • surgeon
    • results of tissue research + results multidisciplinary team
    • medical check-up
  • 6 weeks after discharge
    • nurse specialist
    • evaluation recording
    • medical / nursing check-up
    • explanation follow-up schedule
    • scientific research, if necessary. Referral research nurse
    • referral for genetic testing if necessary
    • make follow-up appointments for follow-up checks

The question on the page originate from the summary of the following study material:

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