Epigenetic factors
4 important questions on Epigenetic factors
What is epigenetic? And what are the main mechanisms?
epigenetic is:
- External modifications to DNA that turn genes 'on' or 'off'
- 'above genetics' does not alter DNA sequence, but affects gene expression
Main mechanisms:
- DNA methylation
- Histone modification
- Non-coding RNA
Epigenetics and DNA methylation
verkeerd plaatje:
- Addition of a methyl group to a cytosine base at a cytosine-guanine dinucleotide (CpG)
- Hypermethylation of CpG sites in promoter regions of genes is related to gene silencing (tissue specific)
- repressed gene transcription
- relatively reduced transcription
Diet in early life and DNA methylation (some studys/hypothosis) (4)
- Developmental origins of health and disease (DOHaD)
- Barker hypotheis
- Fetal programming hypothesis
- Early origins hypothesis
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The Dutch hunger Winter Study
Stijging van
- Obesity
- Type 2 diabetes
- Coronary heart disease
- Kidney disease
The question on the page originate from the summary of the following study material:
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