The ageing gut
8 important questions on The ageing gut
What are the microbiota-derived molecules, metabolites and neuroactive molecules AND nervous system and behavioural changes from the gut microorganism Lactobacillus reuteri?
regulates neuronal plasticity
- increase social behaviour
- increase oxytocin levels
- increase oxytocin neurons
What are the microbiota-derived molecules, metabolites and neuroactive molecules AND nervous system and behavioural changes from the gut microorganism Lactobacillus rhamnosus?
- decrease stress responsiveness
- decrease anxiety and depressive-like behaviour
- increase vagal mesenteric nerve firing
What is known about the mucus in the epithelial integrity?
Loose non-attached mucus layer
- expanding in volume
- built around a MUC2 network
- bacterial habitat
Firmly attached mucus layer
- Stratified organisation
- built around a MUC2 network
- Impervious to bacteria
- Creating a sterile compartment
- Mucin 2, other compounds from goblet cells (mucin2 = mucus protein)
- IgA
- Higher grades + faster learning
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What is known about the mucus in the epithelial integrity?
Loose non-attached mucus layer
- expanding in volume
- built around a MUC2 network
- bacterial habitat
Firmly attached mucus layer
- Stratified organisation
- built around a MUC2 network
- Impervious to bacteria
- Creating a sterile compartment
- Mucin 2, other compounds from goblet cells (mucin2 = mucus protein)
- IgA
What is part of the gut brain axis inflammation
- Hypothalamic inflammation
- increased GI permeability
- loss of muscle mass and function
- low-grade inflammation
- (patho-)physiological trigger, e.g. Tumour
What was studied in the Protégé Study?
intestinal permeability is better
What are the influences of dehydration?
intestinal fatty acid-binding (iFAB) protein has highest in the people that were dehydrated
- iFAB is linked with damaging of the intestine
- the 50% ... were lowest
- citrulline is low in dehydrated people
- SLPI: anti-inflammatory + inhibition of LPS
- SLPI concentration in saliva is influenced by it
What is the difference between feed tube on the stomach or on jejunum?
- Protein
- no large difference
- Carbohydrates
- no large difference
- Gut hormones
- big differences
- more hormones when feed tube on jejunum (glucagon-like peptide 1 and 2)
- Gut hormones
- CCK hormones are high when feed tube on jejunum (this is not really wanted in every person)
- Gut hormones GLP2 as target
- big differences
- more when feed tube on jejunum
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
