Age-related changes in muscle functioning

6 important questions on Age-related changes in muscle functioning

What can you tell about inflammaging as a reason for anabolic resistance?

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What can you tell about decreased protein intake?

  • Official guideline: 0.8 g/kg/d
  • Scientific expert consensus: 1.0-1.2 g/kg/d

  • 28% below 0.8
  • 54% below 1.0

  • Protein division over the day is important
  • 25-30 gram per main meal to reach anabolic threshold (35 g is optimal dose)

  • protein intake at breakfast is 10gram

  • Extra mTOR stimulation
  • Increases muscle mass
  • Accelerates ageing
  • Balance is important

What is the reason for an increasing gap between muscle mass and muscle strength?

Decreased muscle quality

muscle quality = function/mass
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What happens when you are in hospitalisation?

Older adults receiving elective hip replacement:
  • average hospital stay: 5.6 d
  • average quadriceps volume change: -3.4%



  • 13 d of hospitalization
    • mobile (able to walk)
    • vs
    • immobile (wheelchair-bound / unable to walk)

What happens when you have immobilisation

In 23-year olf males
already 5 days of leg-cast decreases volume, lean mass and strength

What happens when there is an increased anabolic resistance during critical illness?

  • Total absence of PA
  • increased insulin resistance
  • increased muscle protein breakdown
  • increased inflammation

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