Age-related changes in muscle functioning
6 important questions on Age-related changes in muscle functioning
What can you tell about inflammaging as a reason for anabolic resistance?
What can you tell about decreased protein intake?
- Official guideline: 0.8 g/kg/d
- Scientific expert consensus: 1.0-1.2 g/kg/d
- 28% below 0.8
- 54% below 1.0
- Protein division over the day is important
- 25-30 gram per main meal to reach anabolic threshold (35 g is optimal dose)
- protein intake at breakfast is 10gram
- Extra mTOR stimulation
- Increases muscle mass
- Accelerates ageing
- Balance is important
What is the reason for an increasing gap between muscle mass and muscle strength?
muscle quality = function/mass
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What happens when you are in hospitalisation?
- average hospital stay: 5.6 d
- average quadriceps volume change: -3.4%
- 13 d of hospitalization
- mobile (able to walk)
- vs
- immobile (wheelchair-bound / unable to walk)
What happens when you have immobilisation
already 5 days of leg-cast decreases volume, lean mass and strength
What happens when there is an increased anabolic resistance during critical illness?
- Total absence of PA
- increased insulin resistance
- increased muscle protein breakdown
- increased inflammation
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