L7 Autism

5 important questions on L7 Autism

Mind altering intestinal microbes are

  1. Microbes affect gut barrier function & mucosal immune system
  2. Microbes can induce neurotransmitters production
  3. Microbes can produce neurotransmitters and metabolites reach and affect the brain
  4. Microbes can reach the brain??

What are the characteristics of autism spectrum disorder?

Neurodevelopmental disorder:
  • disturbed social interaction
  • repetitive behavior
  • impaired communication

Gut-brain-axis of autism

  • changed microbiome composition
  • impaired intestinal barrier

  • abdominal problems
  • strong correlation between gut problems & ASD severity
  • (mild) mucosal and systemic inflammation

  • gut-brain communication is important for brain development & function
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What are the effects of antibiotic on autism

Early life antibiotics (including during pregnancy) is associated with autism in mice & man
  • confirmed in a Dutch & Swedish twin study
  • preclinical study shows causality

Targeting microbiota-gut-brain axis in autism can improve ...

  • improving gut health: microbiome
  • improving immune function
  • improving synapse function

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