L8 Depression

9 important questions on L8 Depression

What are adverse health consequences of depression and that are of the societal costs?

Adverse health consequences
  • Premature death
  • Cancer
  • Diabetes
  • Cardiovascular disease

Societal costs
  • Stigma and discrimination
  • Work absenteeism and unemployment

What is a healthy diet?

  • Contains all nutrients
  • Right proportion of all food groups
    • Dairy
    • Proteins
    • Pulses and legumes
    • Vegetables
    • Fruits
    • Grain foods
    • Oils and fats
  • National dietary guidelines differ per country

Who can nutrition also involve food-related behaviour and what are the influences on food-related behaviour

  • Nutrition also involves food-related behaviour
    • choice of foods
    • food patterns
    • food-related practices
    • psychological eating behaviour
  • influences on food-related behaviour
    • environmental cues: rime constraint, emotions etc.
    • food-related cues: quality, exposure, skills etc.
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What were the conclusions until MOODFOOD

  • Lack of conclusive evidence on the role of diet in the prevention of depression, growing body of evidence
  • Long-term depression prevention trials were lacking (MooDFOOD trial was needed)
  • Unclear whether nutrition influences development of depression in a direct manner or whether other mechanisms are involved as well

What is the conceptual model of the mood food study

Food intake & behaviour <---> Depression
Food intake & behaviour <---> Obesity

Obesity <---> Depression
Social environment ---> Food intake & behaviour
Depression <---> Social environment

Which dietary patterns are used in the MOODFOOD study

  • MDS - Mediteranean Diet Score
  • AHEI-2010 - Alternative Healthy Eating Index
  • DASH - Dietary Approaches to Stop Hypertension

What was the cohort-specific measure of depression in the MOODFOOD study?

Continuous - depressive symptoms
  • depressive symptoms - questionnaire-based score
  • models adjusted for baseline depressive symptoms

Dichotomous - high depressive symptoms
  • based on court-specific cut-off for questionnaire-based score
  • those with high depressive symptoms at baseline excluded

Adults following a healthy dietary pattern have:

  • Fewer depressive symptoms
  • lower risk of developing high depressive symptoms

How does the design of the MooDFOOD study looks like

Food-related behavioural activation vs multi-nutrient supplement


The multi-nutrient supplement consist of:
  • O3FA, Calcium, Selenium, Folic Acid, Vit D3


The food-related behavioural activation consist of:
  • dietary intake, food preparation, food shopping, regular meals and snacking

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