NP3a Bariatry and Ghrelin

6 important questions on NP3a Bariatry and Ghrelin

When is bariatric surgery done?

  • Applied at BMI > 35

  • Increase energy expenditure <<-->> decrease intake

What is Roux-en-Y Gastric bypass (PYGB)

Ghrelin levels decrease
the pancreatic juices + gall will only get to the food later in the small intestine


The stomach is cut and the small intestine.

What is EndoBarrier therapy (not surgery)

  1. An endoscope is used to check the area before placement
  2. a capsule is introduced to place and adjust the liner
  3. the liner is anchored to the upper part of the intestine
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What is done for duodenal mucosal resurfacing?

Hot water burns away the mucosal layer of the small intestines and it is being renewed thereafter --> improved signaling to pancreas

How is Ghrelin regulated

When the stomach is empty, gherkin is secreted. When the stomach is stretched, secretion stops.

Upregulates
  • fasting, low BMI
  • Leptin
  • GHRH
  • thyroid hormones
  • testosterone
  • parasympathetic activity

Downregulates
  • Food intake, high BMI
  • glucose
  • insulin ]somatostatin
  • GH]GHS, ghrelin
  • PYY

What are the effects by Ghrelin?

  • Growth hormone release increases
  • ACTH and cortisol release increases
  • Prolactin release increases
  • Prolactin release increases
  • Appetite increases
  • Carbohydrate metabolism increase/decrease
  • Gastric motility increases
  • Sleep increases
  • etc

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