Tutorials (3-4)

5 important questions on Tutorials (3-4)

What are regioselective reactions?

Reactions where only one of two possible orientations occurs

What is makovikov's rule?

- In addition of HX to an alkene, the H attaches to the carbon with fewer alkyl substituents
- and the X attaches to the carbon with more alkyl substituents

What can you tell me about the stability of carbocations?

It increases with increasing substitution
- alkyl groups offer minor electron donation via sigma bond, which stabilizes the + charge
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What can you tell me about E2 reaction?

- A strong base is needed (OH- or RO-)
- Kinetics E2
-> one step reaction
-> bimolecular: rate depends on the concentration of alkyl halide and base
-> analogous to the SN2 reaction

What can you tell me about E1 reaction?

Kinetics E1
- Multi-step reaction via carbocation intermediate
-> step one is rate-limiting
- unimolecular: rate depends only on the concentration of alkyl halide
- analogous to the SN1 reaction

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