Bone erosions in RA

5 important questions on Bone erosions in RA

Explain the bottom bone line in RA

In rheumatoid arthritis patients an increased bone resorption and a decreased bone formation lead to bone erosion formation

Which inflammatory cytokine can induce DKK-1 activity in Rheumatoid synovial fibroblasts?

TNF-a

Which cells are most involved in the bone erosion in RA?

Osteoclasts
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Which molecules potently inhibit the Wnt ligands and BMPs?

Sclerostin and DKK-1

What seems to happen in bone of RA patients when the inflammation subsides?

Normal coupling in bone remoddeling is partially restored.

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