Systemic bone loss in RA

5 important questions on Systemic bone loss in RA

Which two phases have been recognized in RA?

  1. autoimmune phase (induced by environmental factors)
  2. inflammatory phase (infection or other env. trigger)

What is said about the autoimmune phase of RA?

It can be induced by environmental factors and then slowly develop in the background, before clinical symptoms arise.

What are the mayor bone structure alterations in RA?

  • reduced BMD
  • cortical bone thickness
  • increased fenestration (bone laying bare)
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How does the autoimmune phase increase the chance of the inflammatory phase?

The autoimmune phase induces the accumulation of antibodies that induce fenestration of the bone and thereby allow more crosstalk between the bone and the synovial tissue.

Which tissue contributes to the onset of the inflammatory phase?

The synovial tissue that might get 'inflamed' due to the RA antibodies produced as an autoimmune reaction.

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