The role of subchondral bone in OA

4 important questions on The role of subchondral bone in OA

Which pathway controls the effect of osteocytes on osteoblasts?

The Wnt b-catenin pathway.

What is the effect of mechanical loading on osteocyte function?

Production of sclerostin is reduced, which results in increased bone formation.

What happens to the expression of sclerostin and Wnt pathway in OA patients?

Sclerostin goes down, Wnt goes up
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Which cell types are involved in the deteroriation of remoddeled subchondral bone?

  1. osteocytes
  2. osteoclasts
  3. chondrocytes (cartilage)
  4. osteoblasts

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