Indtoduction - Malaria transmission to mosquitoes
9 important questions on Indtoduction - Malaria transmission to mosquitoes
Why are low-density infections interesting?
2. No symptoms & not found with diagnostics
Where do gametocytes hide?
How do gametocytes sequester in the bone marrow?
After this, it takes a few days before the gametocytes reach peak infectivity
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Why do you need RNA diagnostics to qualify the stages that can be detected in blood?
When did they see the first gametocytes appearing after infecting people? And did this differ between the blood stage group and mosquito bite group?
More female than male, because 1 male gametocyte can make 8 male gametes that can find a female
Blood stage group 10-100x higher gametocyte prodution
How can a Ugandan study report 90% of infections coming from asymptomatic cases, while a Cambodian study reports >95% came from clinical cases?
What is the Entomologic Inoculation Rate?
What happens with an increasing density?
How can naturally acquired immune responses affect transmission?
2. You can have immunity that affects transmission when you start producing antibodies when RBCs are being cleared as the immune system sees antigens. So when female and male gametes are taken up by mosquito, the gametocyte antibodies may recognize the gametes and inhibit their development
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