Indtoduction - Controlled human infection models
3 important questions on Indtoduction - Controlled human infection models
What is the fail fast principle?
With early clinical testing you invest more in the beginning to have lower costs in the end.
How are controlled human infection models useful for malaria?
They help identify failing vaccine candidates. If candidates show promise, they can be improved in antigen (combinations) or adjuvants. CHI trials can accelerate vaccine development.
What interesting findings on Katayama fever were found in a CHI trial?
1. Katayama fever (acute schistosomiasis) was not related to the eggs as previously thought, because people also had Katayama fever when they were infected with only male or female parasites.
2. Katayama symptoms weren found in people with higher doses of cercariae.
2. Katayama symptoms weren found in people with higher doses of cercariae.
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