Articles - Trypanosoma
13 important questions on Articles - Trypanosoma
How is the bloodstream form protected against complement mediated lysis?
Where does the bloodstream form trypanosome express VSG?
Where does the metacyclic trypanosome express VSG? And when are they active?
They are active immediately after infection, but are quickly silenced when the parasite switches to exclusive activation of one of the bloodstream form VSG expression sites
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
For my 1st exam I got a C. Then, I started looking for ways to learn better and I came across Study Smart. Since then I have scored a A+, A, A- and another A. I highly recommend it to everyone who wants to hear it. I am so happy with it!!
I was struggling to finish all my first-year subjects for 3 years. Then I discovered Study Smart, which helped me to finish all of them within 3 months.
Because of StudySmart, things are going well in many ways. Before, I always had study stress and no time for anything. Now I feel calm and confident (because of the program). I used to score a B, now I usually score an A or A+.
Hey Chris, I really want to thank you very much for developing the platform, I usually got around C for my exams, now I scored an A+, an A and a A- !!
Since using Study Smart, my average has increased significantly. I even completed a statistics course with a A+ while I'm bad at statistics. I took on extra courses this year, because of Study Smart. Thanks so much!
Ever since I started studying with StudySmart I passed all my exams !!! No more re-sits!! At first, I was happy with a pass and now I only get good grades. Many thanks!
I aced all the courses I studied with Study Smart. For law, I first scored a D, and now an A! I’m 100% sure that I’ll pass all the courses I study with Study Smart.
I always thought I studied well. My grades were fine. I could never have imagined that applying these study skills would have such a huge and direct impact on my grades, my speed and the pleasure I have in learning.
For the first time, I finally feel totally confident about the way I learn. I have the perfect overview and make great progress in terms of speed and the grades I get. Thanks, Chris!
I immediately started to enjoy learning again, and my grades soared. All of a sudden, everything went better. I highly recommend Study Smart to all students..
Being able to create my materials online made the process of studying so much smoother and quicker. I no longer have to spend a huge amount of my time on creating my summaries.
At first, my notes were a mess. Now I use Study Smart to take my notes in a perfectly structured way. It helps me to save a lot of time and do other things I enjoy.
Students that study with Study Smart get better grades. The system applies all the learning methods in such a way that both well-performing students and students who struggle perform much better.
Hi Chris, I would like to thank you very much. Last year I scored C on a course, and this year I got an A+ thanks to your method! Thank you very much!
The largest effect is that my child is more enthusiastic about school! Every parent wants their children to be happy at school, Study Smart made it happen.
In high school, I failed several exams, and that has really changed now. I actually needed this tool very much back then. Since I started studying with StudySmart, I haven't had any D's. My average score is now an A and those are results I would have never had in the past
With my old method, I passed only 3 out of 8 courses. Since I started taking my notes digitally in Study Smart, I have passed all my courses on the first try. For me, StudySmart takes away the stress of wondering if I will pass or not.
Thanks to StudySmart, I passed all my exams, and with better grades than before! On top of that, I have mastered a very good study method now, which I am confident will help me earn my degree.
At which locations can you find VSG genes? And how many?
2. Telomeric VSGs (minichromosomes), 150-250
3. VSGs in bloodstream form VSG expression sites, 20
What are the switch mechanisms and how do they work?
2. Telomere exchange, the telomeres switch
3. In situ switch, active expression site is silenced while a silent one is activated
Which switch mechanism is the most important and why?
Which VSG genes are activated early in an infection?
How do you get mosaic VSG?
How did VSG pseudogenes accumulate?
2. Telomere: they are located on telomeres where there is little homology so less repair
3. Generation: when generating new VSG genes, many non-functional VSG genes are generated
How can the large amount of VSG genes be advantageous?
2. Pseudogenes cause the different VSG genes to have different activation frequencies, so you get more diversity in a population of trypanosoma
How can the diversity of VSG genes be maintained?
2. Transcriptional switch: you only switch the site where the genes are being expressed, however, selection pressure
3. Telomere exchange: this can occur on the minichromosomes where there are nog VSG genes and which is an important place to store VSG genes. There is little selection pressiure
How can you have multiple expression sites but only 1 is being expressed?
2. Most silent VSG genes are inverted so you dont read them in the same direction
3. Boundary elements are in between housekeeping genes and VSG genes, they stop expression
Why are many genes located on telomeres?
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
