Summary: Parmacology
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1 Parmacology
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three ways a drug can be classified
by usage- why the drug is used, by body system- where the drug works, and by chemical or pharmacological class- what the drug is made of -
requirements regarding handling controlled substances
controlled substances must be in locked drawers within a second locked area- double locking, facility must keep a record of every dose administer, only a subscriber with a national provider ID number -
What are local effects
effects that occurs at the site of application- so no or limited absorption occurs -
What are systemic effects
when the drug must be absorbed into the blood stream before it can go to a distant location for effect -
What is a lipid soluble
dissolvable in fats -
What are "un-bound " drugs
"free" can produce pharmacological effects because only free molecules can be metabolized or excreted -
What is metabolism and what is the main organ for this
Chemical inactivation of a drug through its conversions into a more water- soluble compound or into metabolites that can be excreted from the body.
-----The liver -
what other organs play the minor role in metabolism
kidneys, blood plasma, lungs and intestinal mucosa -
What is the first pass effect of metabolism
When meds are absorbed into the GI tract and circulate through the liver before they reach the system---many can be inactivated in passing through the liver -
What is excretion and what is the main organ involved
when drug molecules are removed from their sites of action and eliminated from the body---kidneys
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