The GI tract
6 important questions on The GI tract
What damage is caused by auto-immune gastritis?
- Neuro-endocrine cell hyperplasia
- Anemia (because intrinsic factor is needed for B12 uptake, and B12 uptake is needed for red blood cell production)
What are the steps of the development of a gastric adenocarcinoma?
What are the two types of gastric adenocarcinoma?
- The diffuse type: thick stomach wall, no glands are being formed, the cells have lost their adhesion molecules and the tumor is diffused in the whole stomach.
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What is the 'old-fashioned' screening method like?
However, this is quite invasive.
What could be ways in which the adenomas with highest risk of progression to adenocarcinomas are selected?
- Histological type: maybe potential for the future, but too risky now.
- Grade of dysplasia: you would miss the majority.
- Chromosomal abnormalities: some are very common in colorectal cancer, but in screening considered to be too difficult.
Which of the before-mentioned ways of selecting the high-risk adenomas is very promising?
- This has not yet been implemented.
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