The hematopoietic and lymphoid systems - The lymphoid systems
23 important questions on The hematopoietic and lymphoid systems - The lymphoid systems
What are the parts of the lymphoid systems?
- Lymphoid organs and extranodal tissue
What is the difference between B- and T-lymphocytes in terms of their maturation?
- the B-lymphocytes mature in the bone marrow,
- the T-lymphocytes mature in the thymus (the common lymphoid progenitor travels to the thymus)
How is T-cell maturation and differentiation regulated in the thymus?
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What are the parts of a lymph node?
- Medulla
- Paracortex
- Cortex with primary and secondary follicles
What is the cortex of a lymph node surrounded with?
What process takes place in the follicles?
What process takes place in the paracortex?
What is the function of the sinuses?
What is meant by follicular hyperplasia?
Therefore, follicular hyperplasia is most often benign.
What is meant by paracortical hyperplasia?
Therefore, paracortical hyperplasia is most often benign.
What is meant by sinus histiocytosis?
What is the difference between leukemia and lymphoma?
- Lymphoma = malignant cells in lymphoid organs / lymphoid structures forming masses
What are the 4 types of B-cell lymphomas?
- Cancer of naive B-cells (mature B-cells)
- Mantle cell lymphoma
- Chronic lymphocytic leukemia
- Follicular lymphoma
- Burkitt lymphoma
- Hodgkin lymphoma
What are the characteristics of non-Hodgkin lymphoma?
- Distribution is unpredictable and dependent on the type
- Staging only limitedly correlates with the outcome
What is the difference between indolent and agressive non-Hodgkin lymphoma?
- Agressive: immediately requires treatment.
Based on what four criteria are lymphomas characterised?
2. Immunophenotype: protein expression
3. Genetics: translocations or mutations
4. Clinical features: location of lymphadenopathy/mass
What are the most prevalent lymphoma types?
- Multiple myeloma
Which gene is overexpressed in follicular lymphoma?
What kind of DNA alterations are very common in malignant lymphomas?
Which gene is translocated in Burkitt lymphoma?
Which two things are characteristic for Burkitt lymphoma?
- It is endemic in Africa (primarily in young people)
When is the prognosis of Hodgkin lymphoma good?
- When the patient has no B-symptoms (like fever)
What is the histological hallmark of Hodgkin lymphoma?
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