Introduction to the brain and neurodegeneration

6 important questions on Introduction to the brain and neurodegeneration

What are the sequences in the amyloid cascade hypothesis?

  1. Increased AB production
  2. Decreased clearance of AB
  3. AB oligomers
  4. AB fibrils
  5. Synaptic and neuritic injury
  6. Inflammation/oxidative injury
  7. Tau phosphorylation
  8. Tangles
  9. Neuronal dysfunction/loss
  10. Dementia

Which protein accumulates in parkinsons disease?

Alfa-synuclein

Which protein accumulates in frontotemporal dementia?

TAU and TDP43
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What is the causative agent of prion diseases?

Abnormal form of a cellular protein

How are neurodegenerative diseases characterized?

By the progressive loss of neuron, typically affecting groups of neurons with functional interconnections

What is the harmless solube protein of amyloid precursor protein?

The protein that is cleaved by a secretase and y secretase.

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