Hedgehog pathway - Cillia problems

6 important questions on Hedgehog pathway - Cillia problems

Name a pathway example of mechanoreception + place.
Name an example of chemoreception with IFT + place

Mechano: Wnt pathway. In vestigulocochlear organs (oor), renal tubules,
Chemo: HH pathway. In photoreceptors.

So, what is the link between cilia and hegdehog?

Cilia problems (abnormal axoneme + intraflagellar transport) => wrong distribution of hedgehog proteins + pathways.

So what is the link between centrosomes and cillia?

Formation of cillia form centriolen
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart

So one function of the cilia is propulsion. There are different kinds of propulsion, which ones and is this important?

Hensens’s node (=Primitive node) => cilia have a circle like motion. -> result in asymmetric deposition of molecules => specific pathways are exposed on one side. => disorders in this process can be lateralical defects. Heterotaxia = transpositie van dingen (hart bijvoorbeeld)

What is the genetic background of ciliopathies?

Genetic heterogeneity and pleiotropy (=more than one phenotype)

Name examples of non motile ciliopathies (heritable disorders, defect in shape or function)

Renal tubes. Polycystic kidney disease (PKD).
Vestibulocochlear organs

The question on the page originate from the summary of the following study material:

  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo