Summary: Pharmacology
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Pharmacology
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Indirect cholinergic agonists (AChE inhibitors)
saran, nerve gasses, insecticides, neostigmine, pyridostigmine -
Nicotinic receptors are blocked by
Competitive neuromuscular blockers -
What class of receptors does the muscarinic receptor belong to?
GPCR -
What class of receptors does the nicotinic receptor belong to?
Ion channel (Inward Na+ channels that cause depolarization) -
Where are muscarinic receptors found?
In effector cells innervated by post-ganglionic parasympathetic nerves -
Where are nicotinic receptors found?
Autonomic ganglia + motor end plates -
M1 and M3 use which GPCR subtype?
Gq (IP3 an DAG cascade) -
M2 uses which GPCR subtype?
Gi (inhibition of cAMP production and activation of K channels) -
Stimulation of M1 in the CNS causes
Cognition, Memory, Seizures -
Stimulation of M2 in the CNS causes
Antinociception, hypothermia, tremor
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