Ileum tutorial

8 important questions on Ileum tutorial

Length of time (agonist)

-may be constant throughout an experiment
-may vary between different experiments

To generate a full response

It is not always necessary for all receptors to be occupied

Reversible competitive antagonists

Associate and then dissociate from the receptors: they do not stay associated with the receptors.
-> the effect of the antagonist can be reversed.
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Irreversible competitive antagonism

Associate and STAY ASSOCIATED WITH the receptors. The receptors are therefore blocked and increasing the agonist concentration has no effect: since the receptors remain blocked

Physiologial/functional antagonist

Acts on separate cells or a separate physiological system to that of the agonist.
not directly affects system 1

Difference between readings for agonist and first concentration of agonist

= 1
-> antilog 1 = 10

Reversible competitive antagonist


If a reversible competitive antagonist is used, the results can be used to find the pA2 value of the antagonist. The pA2 value is a measure of the potency of the antagonist: the more potent the antagonist, the higher the pA2 value.

Concentration antagonist increases

The maximum response does not change

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