Elimination and clearance
7 important questions on Elimination and clearance
What is the volume of distribution?
For example you do not know the volume of the fluid, you can calculate the volume by knowing how many drug goes in and what the concentration is.
Lets say your body has a volume of 90 kg. When the volume of distribution is 90, the drug is more or less divided over the whole body. If the Vd in the plasma is 1000, you know it is not even spreaded.
What can be a negative side of a long half-life?
What is the role of tissue protein binding on drug distribution?
When a lot of drug bind to proteins in a tissue, there might be needed a larger dose to get the same effect. It also takes longer to break down the drug or remove it form the body.
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What is the role of plasma protein binding on drug distribution?
Which organs are mainly involved in the elimination of a drug?
Also skin, intestines and lungs can play a role.
What is extraction ratio?
How is clearance connected to half-life?
The formula of Cl has a value that is dependent on the half-life.
This formula for Cl only applies when there is first order!
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