Food drug interactions

11 important questions on Food drug interactions

What happens with the case where a man started to drink cranberry juice?

He took a medicine with warfirin. When he started drinking cranberry juice there was an interaction between the two and this inhibited the CYP4502C9. Therefor there was no bloodclothing anymore and the man died of internal bleeding.

Drug on a full stomach or empty stomach?

This is depending on the drug. Some drugs can stay in the stomach for a long time without doing harm, but a lot of drugs cant stay in the stomach long because they are harmed or the stomach can be harmed.
This can also depend on the form of the drug. Capsules can be longer in the stomach than a tablet for example.

What is the Biopharmaceutics classification system (BCS)? [FDA]

Drugs are divided into high or low soluble in water, and in high or low permeable through membranes.
When a drug is high soluable and high permeable, that is a good drug without much side effects, like paracetamol.
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What is the effect of high fat meal on the BCS?

Class 1: bioavailability stays the same, only the time of absorption will be longer.
Class 2: the bioavailability will be higher and time of absorption is depending.
Class 3: will have a lower bioavailability and a longer absorption time.
Class 4: this is all really dependent and different. These are the new drugs who are a bit difficult and more complex.

What is brick dust?

This is a molecule that does not dissolve in water or in fat, therefore it can be really different and difficult. This is in class 4 and this class is increasing.

What are examples of food interaction with CYP450?

These are the most famous food-drug interactions with CYP450 you should know/recognise.

What drugs are more interacting with grapefruit?

These drugs are all increasing in combination with grapefruit.

Why should you not change from diet when on a lot of drugs?

Fibers may affect the absorption of some drugs. Therefore you should not change your diet much when on a lot of drugs. This may change your fiber intake and thereby the absorption of your drugs. This could be dangerous.

Why do all drugs react different, also when in the same therapeutic classes.

It could be that they are metabolised different, therefore different processes take place and different interactions. Also the chemical properties differ.

What is Saquinavir and indinavir?

Saquinavir: presence of food in stomach improves dissolution.
Indinavir: precipitates in stomach due to higher pH after meal rich in proteins or fat.

What can be reasons for mallnutrition caused by drugs?

Oral health and functioning
Taste and smell
Appetite and satiation (+ or -)
GI physiology (diarhoea)
General metabolism
Micronutrient absorption and metabolism
Microbiota

The question on the page originate from the summary of the following study material:

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