Autonomous nervous system ANS

10 important questions on Autonomous nervous system ANS

What is the autonomous nervous system (ANS)

It is a really important physiologically regulatory system.
Lot of drug interfear with the ANS.

What is afferent and efferent?

Afferent are action potentials going toward the central nervous system
Efferent are action potentials comming from the CNS

What happens when you stimulate beta2 receptors?

They are in your lungs, uterus, liver and muscles.

agonist:  it will get you muscles and it helps against asthma.

antagonist: beta blockers were not specific. That is why bronchiconstriction was a side effect for lowering of bloodpressure.
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What happens when beta3 receptors are stimulated?

This was a big come through because they thought is was a way to burn fat. It is thermogenic, this means it is a receptor on your brown fat tissue. Turns out, it only works in hibernating rodents...

What happens when stimulating alpha1 receptors?

They are in your bloddvessels, vasoconstriction.

Agonist: It could be used in the nose for vasoconstriction
Antagonist:  It could be used to relax the muscles around the uteris in man. To help them pie.

What happens when alpha2 receptors is stimulated?

Not really important for drugs anymore.

agonist:   vasodilation
antagonist: (green viagra) vasoconstriction, local swelling.

What are indirectly acting sympathomimetics

Something that resembles/mimics sympathetic nervoussystem actions. They act different, but the result is the same.

Sympathiolimics are the opposites, they inhibit.

Is there use to stimulate the parasympathetic nervous system?

There could be, some people have a lot of pressure in ther eye, than you can use those to releave the pressure.

SLUD, side effects.

Antagonists can be used in the parasymphatetic nervous system:

Atropine blocks the parasympathetic nervous system. So the opposite (sympatethic nervous system) will happen.

Scopolamine can prevent motion sickness.

curare, this was used to hunt, the neurons are blocked and you can not move anymore. Your hart will continue but you cant breath anymore.

What happens if you stimulate the beta1 receptor (sympathetic nervous system) with an agonist or antagonist?

Agonist: Contratilitie and hartfrequentcy will be stimulated. This is hardly used because it could be dangerous, only for cardiologists.

Antagonist: beta-blocker. it inhibits your sympathetic nervous system, this will decrease the hartrate and the vasoconstriction. It is there to lower your bloodpressure, for example when you are stressed.

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