BETA-SITE APP CLEAVING ENZYME
4 important questions on BETA-SITE APP CLEAVING ENZYME
How does APP contribute to the formation of b amyloid?
One of the APP cleaving enzymes in AD is BACE1, it seems to be upregulated in Alzheimer neurons. what was the effect of inhibiting this enzyme?
Name a potent inhibitor of the BACE1 cleaving enzyme:
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How may exercise reduce amyloid production in Alzheimer's Disease?
For example, exercise may reduce ER stress, which decreases BACE1 expression
By decreasing BACE1 expression, less APP will be cleaved. Cleaved APP becomes an amyloid beta monomere, which can aggregate outside the cell.
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