APOLIPOPROTEIN E

5 important questions on APOLIPOPROTEIN E

What is apolipoprotein E?

A cholesterol transporter and Amyloid beta metabolism regulator synthesised by glia and pathologically by neurons.

How may APO E contribute to amyloid beta pathology in Alzheimer's Disease?

APO E is a lipid and if the lipid homeostasis in the brain becomes disturbed the APO E will have altered effects on amyloid beta metabolism.

What may be the effect of physical exercise on the aggregation of amyloid beta seen from an APO E perspective?

Exercise improves lipid homeostasis throughout the body. APO E malfunction in AD may be caused by a disturbed lipid homeostasis in the brain. Exercise can improve this lipid homeostasis and therefore reduce the amyloid beta aggregation.
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Exercise may improve cognitive performance in AD in a non-amyloid dependent way in APO E4 carriers. Which way?

By improving perfusion (mottige vaten) and neurogenesis

Why whould it come in handy to know the APO E genotype of AD in determining treatment?

APO E4 carriers wit AD may benefit more from physical exercise therapy than others

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