NEPRILYSIN/INSULIN-DEGRADING ENZYME

5 important questions on NEPRILYSIN/INSULIN-DEGRADING ENZYME

What are both NEP and IDE important regulators in?

The clearance of amyloid beta

Which cells secrete IDE?

neurons and microglia

What is observed in aging and AD?

NEP and IDE levels decrease
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What is the effect of physical exercise on NEP and IDE?

mRNA activity is increased in the cortex and hippothalamus by both low and high intensity exercise. This also works in diabetes.

How can IDE or NEP expression be improved in the brain?

  • Exercise (Kim et al 2011; Maesako et al 2012)
  • Environmental enrichment (Lazarov 2005)

The question on the page originate from the summary of the following study material:

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