PRESENILIN

3 important questions on PRESENILIN

What is the main function of PS1/PS2?

Stabilising the gamma-secretase complex that is involved in the cleavage of APP.

What is the effect of physical exercise on PS1?

It reduces the expression of PS1 and accompanied APP phosphorylation.

What is the effect of physical exercise on PS2?

It inhibits PS2 mutation-induced memory impairments and activation of gamma-secretase.

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