Anatomy urinary system

33 important questions on Anatomy urinary system

What is the anatomy of the renal hilum?

Renal vein (anterior)
Renal artery (middle)
Renal pelvis (posterior)

What is the renal sinus?

Central cavity where urine is collected

What are the parts of the renal sinus?

- Renal calyces (calyx)
  • minor and major calyces
- renal pelvis
- perinephric fat, blood vessels etc.
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What is a kidney lobe?

Medullary pyramid + surrounding cortical tissue. Different nephrons that drain into the same reservoir.

How is the blood supply to and from the kidney?

Kidneys are well perfused because of their filter function

renal artery
segmental arteries
interlobar arteries
arcuate arteries
interlobular arteries
capillary
interlobular veins
arcuate veins
interlobar veins
segmental veins
renal veins

What are the five segments of the kidney?

Apical, anterosuperior, anteroinferior, posterior and inferior

What is the structure of the nephron?

1 = renal corpuscle (of Malpighi), consists of Gomerulus and Bowman's capsule)
2 = Proximal thick segment, consists of convoluted tubule (TC I) and straight tubule (TR I)
3 = thin segment, the thin part of the loop of Henle
4 = straight tubule (TR II) and convoluted tubule (TC II)
Yellow = collecting tubule (outside the nephron), the ductus colligens and ductus papillaris.

black = medullary ray

Where does ultrafiltration takes place?

Renal corpuscle

What is the function of the descending and ascending limb of the loop of Henle?

Descending = passive reabsorption of H2O
Ascending = passive reabsorption of Cl-, Na+ and K+

What is the vasa recta?

Countercurrent exchanger, blood vessels (arteriole rectae and venule rectae)

What is the function of the vasa recta?

Maintain the osmotic gradient of the medulla

What is the function of the proximal convoluted tubule?

Reabsorption of electrolytes and H2O, amino acids and glucose. (120L/day)

What is the (microscopic) difference between the proximal and distal tubule?

Proximal = brush border, junctional complexes, basal triations
Distal =  no brush border

What is special about the blood supply and drainage to/of the glomerulus?

Afferent and efferent arteriole (normally an efferent venule)

What is special about the blood supply and drainage to/of the glomerulus?

Afferent and efferent arteriole (normally an efferent venule)

What is special about the endothelial cells of the glomerular apparatus?

Contain fenestrations

Where does Bowman's capsule consists of?

Podocytes -> pedicels and filtration slits

What are the three layers of the glomerular basement membrane?

1. Lamina rara interna (adjacent to capillary endothelium)
2. Lamina densa
3. Lamina rara externa

What is the function of the glomerular basement membrane?

Physical barrier (lamina densa) and ion-selective filter (laminae rara)

Why is the lamina densa a physical filter?

Type IV and type XVIII collagen, which restricts the movement of molecules >70 kD

Why is the lamina rarae a ion-selective filter?

Rich in polyanions such as glycosaminoglycans, restrict the movement of negatively charged molecules

Where do the slit pores consists of?

Of nephrin, neph1, neph2, P-cadherin and alpha-actinin. The slit pores are connected to the cytoskeleton

Which three cell types are present in the juxtaglomerular apparatus?

  • Macula densa cells
  • juxtaglomerular cells
  • extraglomerular mesangial cells

What are macula densa cells?

A cell type of the juxtaglomerular apparatus.
Specialized cells DT (TR II) at vascular pole
Chemosensor for [Na+] tubular fluid

What are juxtaglomerular cells?

A cell type of the juxtaglomerular apparatus
Modified smooth muscle cells of the tunica media of the afferent arteriole
Synthesize and secrete renin

What are extraglomerular mesangial cells?

Lacis cells, a cell type of the juxtaglomerular apparatus
Modified smooth muscle cells, function unknown

How does the juxtaglomerular apparatus work?

Regulates blood pressure by activating the renin-angiotensin-aldosterone system (RAAS). The RAAS system is responsible for an increase in blood volume and BP

Which structure deliver urine from the pyramids to the minor renal calyces?

Renal papilla (area cribrosa)

How does the urine reach the bladder?

Via the ureters, in the wall smooth muscles are located to push the urine to the bladder with peristaltic movements

There are three constriction sites in the ureters, which three?

1. Ureteropelvic junction
2. External iliac artery and/or pervic brim
3. Bladder wall

How many openings does the bladder has?

3, two for the ureters and one for the urethra

The urethra of men consists of 4 parts and 2 spincters, which parts and which sphincters?

Parts: intramural, prostatic, membranous, penile/spongy
Sphincters: internal, involuntary (bladder) and external, voluntary (lower)

--> in women only one part and only the external, voluntary sphincter

What is the type of epithelium in every part of the tubule?

TCI, TRI = cuboidal
Loop = thick squamous to low cuboidal
TRII, TCII = cuboidal
Collecting duct = cuboidal to cylindrical

vasa recta = thin squamous (endothelium)

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