Cardiac muscle physiology
3 important questions on Cardiac muscle physiology
What is isometric contraction?
Maximal force development, no shortening of the muscle
--> length dependent
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--> length dependent
What is the relationship between force and length and between force and time?
Force & length: the more extended the muscle, the more force is generated -> passive F-L relation = non-linear
Force & time: if length is kept constant, it will provide a constant force. When this muscle (same length) is stimulated, it generates a peak![]()
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--> there is a linear relationship between peak force and length = active peak isometric F-L relation
Force & time: if length is kept constant, it will provide a constant force. When this muscle (same length) is stimulated, it generates a peak
--> there is a linear relationship between peak force and length = active peak isometric F-L relation
How is it possible that at increased sarcomere length there is increased force of contraction?
- optimal actin-myosin overlap
-![]()
reduced lattice spacing
- altered myosin head orientation
- increased Ca sensitivity
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- altered myosin head orientation
- increased Ca sensitivity
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