Vascular function
3 important questions on Vascular function
What are exchange mechanisms across the capillary endothelium?
Diffusion: O2, CO2 and lipid-soluble substances
Bulk flow (flow through clefts and pores between cells): H2O, electrolytes and small molecules
Vesicles: macromolecules
Active transport: ions, small molecules
--> most important are diffusion and bulk flow
Bulk flow (flow through clefts and pores between cells): H2O, electrolytes and small molecules
Vesicles: macromolecules
Active transport: ions, small molecules
--> most important are diffusion and bulk flow
How is flux calculated?
Diffusion: J = D*A
Bulk flow: J = K(F)*A (NFD = net driving force)
Bulk flow: J = K(F)*A (NFD = net driving force)
What happens when NDF < 0?
Reabsorption, fluid is pumped back into the cell
--> on arterial side filtration and on venous side reabsorption![]()
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--> on arterial side filtration and on venous side reabsorption
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