Molecular contraction mechansism
12 important questions on Molecular contraction mechansism
Which 3 muscle types exist?
Skeletal muscle (leg, arm etc)
Smooth muscle (intestines)
--> all contraction by actin-myosin interaction
What are the main functional differences between the muscle types?
What is the anatomy of the cardiomyocyte?
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
What is the hexagonal lattice structure?
What is the function of titin?
Functional: works as (non-linear) spring
- increased stiffness during stretch
- passive 'restoring force' during shortening
What is the anatomy of a myosin filament?
thick filament
What is a myosin II molecule?
What is the function of myosin light chains?
MLC-2 phospholylation leads to cross-bridge interaction
What is the function of myosin head?
What controls the actin-myosin interaction? And how?
The troponin complex regulates the binding:
- tropomyosin is connected to actin, TnT connects to tropomyosin, TnC binds to TnT and TnI binds to TnC and actin.
TnI inhibits binding of myosin by blocking the binding site. Binding of Ca2+ to TnC makes the myosin binding site available
What is the cycle of the cross-bridge between myosin and actin?
2. Released state, ATP hydrolysis
3. Cocked state, cross-bridge formation
4. Weak cross-bridge state, P release
5. Strong cross-bridge state, power stroke
6. Post power stroke state, ADP release
7. Attached state
How does the myofilament generates force (tension) or movement?
Forse when filament sliding is prevented
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding