Summary: Population And Quantitative Genetics
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What are chromosomal polymorphisms?
A condition where one species contains members with varying chromosomes counts or shapes -
What is the coeffcient of variation (CV)?
The standard deviation of the trait divided by its mean -
What is blending inheritance?
A theory that the progeny inherits any characteristic as the average of the parent 'value of that characteristic' -
How do you know the proportion of variance in a traits that is due to additive genetic effects?
With the correlations between close family -
What are the three measures of summary statistics?
- The proportion of polymorphic loci (P)
- The number of different alleles at a locus (A)
- The gene diversity/heterozygosity (H) -
What is restriction mapping?
A method used to map an unknown segment of DNA by breaking it into pieces and then identifying the locations of the breakpoints -
What are the cons of restriction mapping?
- It is limited to regions in or close to coding sequences
- Many variants remain undetected -
Why are protein sequences constrained by natural selection?
Non-synonymous variants cause harmful changes and are eliminated from a population
-> therefore most variants that are dectected in coding sequences are synonymous -
What is SNP detection useful for?
Comparing diversity levels
- but it is not reliable for detecting rarevariants ->resequencing is more reliable -
Information on variant frequencies can be useful for?
- Looking if selection has been acting on a gene
- What kind of selection has been acting
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