Major Histocompatibility Complex (MHC), antigen presentation & T cell activation
7 important questions on Major Histocompatibility Complex (MHC), antigen presentation & T cell activation
Thinking of their structure, what do MHC I and MHC II have in common, what are differences?
Both consist of polymorphic alpha chain noncovalently bound to a polymorphic beta chain. In MHC I, only the alpha chain is glycosilated and much bigger
How are antigens processed in MHC I and II pathways?
What is the B7-CD23 interaction?
DCs also express B7, which is a costimulator for CD23 receptors on CD4+ cells.
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Which cell-cell-interactions are there in the immune system?
non-specific adhesion, Antigen-binding, costimulation and cytokines
What is the role of CD40 in the immune response?
Which effects on the immune system do Th1, Th2 and Th17 have?
Th1 promotes CTLs and IgG production. it is intracellular and associated with autoimmune disease.
Th2 promotes IgG, mastcells and macrophages. it is against parasites and associated with allergy.
Th17 promotes monocytic inflammation. It is against extracellular bacteria & fungi and associated with organ-specific autoimmunity
How do CD4+ cells "help"?
they produce cytokines to co-activate CD8+ cells or help APCs maturing so they can co-activate CD8+ cells themselves.
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