Rectal preparations
9 important questions on Rectal preparations
What are the reasons for rectal administration?
2 Nausea, vomiting
3 Impaired consciousness
4 Severe gastrointestinal complains after oral administration (indomethacin)
5 Unpleasant taste (especially children)
6 Patient is non-cooperative (small child, mentally disabled)
7 Local therapy (hermorrhoids, colitis)
1 Slikproblemen
2 Misselijkheid, braken
3 Verminderd bewustzijn
4 Ernstige maag-darmklachten na orale toediening (indomethacine)
5 Onaangename smaak (vooral kinderen)
6 Patiënt wil niet meewerken (klein kind, verstandelijk gehandicapt)
7 Lokale therapie (hermorroïden/bawasir, colitis/kolon)
What are the 3 reasons to use rectal=
Rectal preparations in pharmacopea rectal dosage forms
What are the kinds of rectal preparations?
Rectal capsules
Rectal solutions, emulsions and suspensions
(Enema, micro-enema)
Powders and tablets for rectal solutions and suspensions
Semi-solid rectal preparations (ointments, creams, gels)
Rectal foams
Rectal tampons
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What are the routes for rectal drugs
Local
dikke darm infectie after de dunne darm very near the anus = rectal
What are the drugs that are given by rectal route for local action?
Haemorrhoids
- Zinc oxide, hydrocortisone acetate, lidocaine
Chronic inflammatory bowel disease
- Mesalazine, beclomethasone
Laxative
- Bisacodyl, docusate sodium
Biopharmaceutics rectal systemic effect
The person goes to the toilet and the drug will be expand from the body
§ No irritation §
Enema: faster action than suppository
Liver first-pass effect partly avoided
ENEMA ACT FASTER THAN SUPPOSITORY BECASUE suppository is fat and enema is vloeibaar?
Lipothilic suppository bases
What does Iodine value mean?
The number of the double bound and thus the ... Of oxydation
How is API released from the suppository? 28
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