Physiology of Exercise - Buffering the exercise-induced lactic acidosis
2 important questions on Physiology of Exercise - Buffering the exercise-induced lactic acidosis
What is the mean of buffering lactate by HCO3 - ?
To minimize the decrease in intracellular pH.
How come that HCO3 - starts slightly later than the increase of lactate? What consequences does that have for the LT and LAT?
The HCO3 - starts to buffer when lactate is increased by approximately 0.5 to 1.0 mmol/L. Before that the H+ is used to split PCr (PCr + ADP + H+ --> Cr + ATP). So the LT slightly precedes the decrease of HCO3 -. So the body reaches the LAT (Lactic Acidosis Threshold) at a slightly higher VO2.
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