Exercise Testing and Interpretation - Factors limiting exercise

5 important questions on Exercise Testing and Interpretation - Factors limiting exercise

What is the functional physiologic definition of fatigue?

The failure of VO2 to reach a steady state and to meet cellular O2 (QO2) requirement

What mechanism with respect to Ca2+ could be responsible for fatigue?

Decreased levels of ATP, low pH reduce force production because myofibrils become less sensitive to Ca2+ and less Ca2+ is released from the sarcoplasmic reticulum. So less crossbridges can be formed.

What is the physiological dead space?

The air that enters the ventilatory tract but does not participate in gas exchange.
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Door welke pathofysiologische verschijnselen kan dyspnea optreden.

  • slechte ventilation-perfusion mechanisme als gevolg van dode ruimtes in de longen
  • lactaat vorming bij lage inspanningsniveaus
  • door inspanning geinduceerde hypoxemia(lage zuurstof druk in het bloed)
  • impaired ventilatory mechanims.

What is the cause of myocardial ischemia?

Inadequate O2 supply to the relative O2 requirement of the myocardium.

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