Lactate increase - Mechanisme of lactate increase - Change in cytosolic redox state due to hypoxia limiting the mitochondrial membrane proton shuttle
3 important questions on Lactate increase - Mechanisme of lactate increase - Change in cytosolic redox state due to hypoxia limiting the mitochondrial membrane proton shuttle
Which molecules determine the cystolic redox state?
It is the ratio between NADH + H+ en NAD+
How does the cystolic redox state ([NADH + H+/NAD+) decrease (harder to reduce NADH + H+)?
Because there is insufficient O2 present [NADH + H+] can not be reduced (O2 is an H+ acceptor), so NAD+ can not be regenerated by O2. Via the formation of lactate (pyruvate + NADH + H+ --> lactate + NAD+) NAD+ can be regenerated.
What is the lowest capillary PO2 for the mitochondria in the muscle to receive the O2 required for exercise? (critcal capillary PO2)
15 mm . It is the lowest PO2 that allow the muscle mitochondria to receive the O2 required for exercise aerobically
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