Physiology of Exercise - metabolic-cardiovascular-ventilaory coupling - Cardiovascular coupling in metabolism: muscle oxygen supply

4 important questions on Physiology of Exercise - metabolic-cardiovascular-ventilaory coupling - Cardiovascular coupling in metabolism: muscle oxygen supply

The proportional increase of the cardiac output is less than the increase of VO2. What mechanism compensates for this discrepancy?

The extraction of O2 from the blood in the capillary bed increases

How much is the difference (P(A-a)O2) between pO2 in the alveoli (PaO2) and pO2 in the arteries (PAO2) during exercise in normal young adults?

10 mm Hg

What are the normative values of PAO2 and PACO2 (= at alveoli)?

100 mm Hg and 40 mm Hg, respectively
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What effect does CO (carbon mono-oxide) have on capillary pO2? And on blood flow - metabolic rate ratio (Qm/VO2m)?

CO binds to hemoglobin so O2 can not bind to these sites. This results in a decrease of arterial O2 content. Because of this capillary pO2 is reached more rapidly. To maintain sufficient capillary pO2 Qm/VO2m needs to increase, so larger blood flow is needed.

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