Propagated Signaling: The Action Potential - Sodium and Potassium Currents Through Voltage-Gated Channels Are Recorded With the Voltage Clamp

4 important questions on Propagated Signaling: The Action Potential - Sodium and Potassium Currents Through Voltage-Gated Channels Are Recorded With the Voltage Clamp

What is the basic function of the voltage clamb?

Fixing the potential between the inner and outer membrane, effectively making the current through the ion channels at a certain voltage measurable.

Why is Ic = 0 during a voltage clambed experiment?

The voltage stays the same, after a brief period of charging the capacitor, effectively leaving the current to flow through the membrane resistance only.

What is the leakage current during constant stimulation?

The dissipation of current through the ion channels in 1 patch of nerve... regarding an axon it is also the loss of energy due to friction.
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How where Hogdkin and Huxley able to distinguish the time course of K and Na voltage gated channels under an applied current?

They blocked 1 of the voltage gated channels to only allow the other to flow.

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