Refresher on neuroanatomy and physiology
6 important questions on Refresher on neuroanatomy and physiology
How does the structure so far translate into function?
Important lesion studies
- Leborgne (Tan) Broca aphasia
- Phineas Gage and the prefrontal cortex
- Modern neuropsychology -> neuroplasticity
- Advancement of brain imaging techniques
Targetting a brain region
The complex structure -> function relationship means that pharmacological targets are involved in multiple functions.
Specific neurotransmitters: total number of neurons (100 billion)
- Some are used y relatively few number neurons (<1%): Norepinephrine, dopamine, serotonine
- Others are much more common (50% of synapses): GABA, Glu, Endocannabinoid receptores
- Even though implicated in disorders/ effects of compounds
- GABA: alcohol, sedatives, anxiolytics
- Glu, NMDA: epilepsy, Huntington, schizophrenia
-> problem with specificity of drug target
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Specific neurotransmitters: precursors (where from)
- Voor de aminozuur neurotransmitters is de precursor typisch het aminozuur zelf, bijvoorbeeld glutamaat, glycine of GABA.
- Acetylcholine (ACh) wordt gesynthetiseerd uit acetyl-CoA en choline als voorlopers.
- Voor de neuropeptiden oxytocine en endorfine worden de precursors gevormd uit grotere eiwitten die in de cel worden geproduceerd en verwerkt tot de actieve neuropeptiden.
Specific neurotransmitters: ending NT activity (where to?)
For example:
- ACh: degradation by extracellular enzyme AChE (then reuptake)
- 5-HTL: reuptake
- Peptides
What are G-protein-coupled receptors?
- Neurotransmitters binds to recepter activating G-protein
- G-Protein submits or intracellular messengers modulate channels
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