L3: Dietary guidelines prevention DM2

28 important questions on L3: Dietary guidelines prevention DM2

What is the world wide trend of the prevalence of DM2?

The prevalence of DM2 increases world wide. From 2019 to 2045. In europe it will be 15% increase. In south and north amerika 30-55% increase. In afrika 143% increase. In missle east and asia 75 - 90% increase.

What are the criteria for diagnosis of DM2?

HbA1c of >6,5%/48 mmol/mol
and
fasting plasma glucose of >7,0 mmol/l
or
2h plasma glucose of >11,1 mmol/l
and
resting plasma glucose of >11,1 mmol/l

Name 7 types of cardiovascular outcomes that diabetes type 2 increases the risk of.

- coronary heart disease
- heart failure
- peripheral artery disease
- stroke
- retinopathy
- neuropathy
- nephropaty
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What is indication of participating with a GLI?

BMI > 25 with additional risk factor for cardiovascular disease, diabetes, sleep apnea or artritis
- bmi >30
- sufficient motivation for a 2 year program

What are the NDF dietary guidelines to prevent diabetes type 2?

Combined lifestyle intervention
it consists of:
- calorie restriction diet with attention for improvement on long term (>1 year)
- increased physical activity
- if needed psychological intervention to suport behaviour change

What is the NDF advice for carbohydrates for prevention of DM2?

- there is no evidence that amount of KH has impact on risk of DM.
- quality of KH seems more important. People with higher quality of KH (fruits, vegetables, whole grains, beans) have lower risk than people with lower quality of KH (sugar sweetened beverages, white bread, cakes, white pasta)

Which 3 foods/nutrient are associated with lower risk of type 2 diabetes?

Yoghurt
coffee
vitamin D

What is the effect of blood pressure lowering treatment for CVD and DM2?

We see a reduced risk of macrovacular complications by blood pressure reduction. Same as for cholesterol lowering

What was the reduction of risk of diabetes for people who participated to the GLI compared to control?

People who did GLI had a 20% lower incidence of diabetes than placebo.
(placebo 40% incidence, gli 20%)

What are the 2 guideline for treatment of diabetes with overweight?

- Recently diagnosed: aim for 5-10% body weight reduction
- gli with professinoal guidance for dietary, physical activity and behaviour change are preferred.

What advice is taken out of the guideline for treatment of diabetes with overweight?

Short term (<1 year) low carbohydrate diet is beneficial in terms of bodyweight, lipids and cardiovascular risk.
There is too little evidence on the long term effect of low carbohydrate diet on weight reduction.

What are the 5 advices of the NHG standard for diabetes patients?

- no smoking
- sufficient physically active
- weight reduction when bmi >25
- healthy diet
- if necessary refer to dietician

What is the advice for Fat intake for people with diabetes?

No optimal en%
reduce saturated fat with unsaturated fat
as little trans fat as possible

What is the advice for suplements for people with diabetes?

Food products high in omega 3 fatty acids improve cholesterol, its not adviced to take supplements but just to eat the fish and nuts.

What is the advice for vitamin B12 and diabetes?

Metformin can cause vitamin B12 deficiency. The consequences can be neuropathy, depression, lower cognitive function
There is insufficient evidence to screen for vitamin B12 deficiency in people who use metformin. So its not adviced.

What is the advice for vitamin D supplementation and diabetes?

Only supplement when at risk of deficiency.

What is shown about weightloss and remission of diabetes?

The higher the weightloss, the higher the chance of remission of diabetes.

Name 6 diets associated with type 2 diabetes

- low carbohydrate diet
- low fat diet
- DASH diet
- vegetarian/vegan
- Paleo
- Mediterranean

What is the advice about low carbohydrate diet for people with diabetes?

- there is no recommendation about en% carbohydrate. There are potential positive short term effects on weight, unknown in the long term. The compliance for low carbohydrate diet is very low.
so: not adviced

What is the advice about DASH diet for people with diabetes?

It is associated with reduced risk of type 2 diabetes, but there is too little research of the DASH diet in people with T2D.

What is the advice about vegetarian diet for people with diabetes?

Associated with reduced risk of type 2 diabetes, but it has in common that it focusses on more vegetables, more fruits, less meat, more plant protein.




What is the effect of vegetarian diet and mediterranian diet on HDL cholesterol for people with diabetes?

Vegetarian: significant lower HDL cholesterol than control.
Mediterranean: significant higher HDL cholesteorl than control.
Vegetarian vs mediteranean: vegetarian significant lower HDL than mediterranean

What is the effect of vegetarian diet, mediterranean diet, low carb diet, low GI/GL diet and high protein diet on HbA1C compared to control?

They all had significant lower HbA1C than control group. Mediteranean had highest reduction of HbA1C compared to control group.

Which 3 diets reduce LDL-cholesterol compared to control in diabetes?

Vegetarian diet, low GI/GL diet, moderate KH diet.
mediterranean, paleo, low KH and high protein did not lower LDL significantly.

What is the PREDIMED study? What were the findings on cardiovascular event risk?

A study in spain for people with high CVD risk. They were randomized in one of 3 groups:
control (normal low fat diet for prevention of cvd, advice is reduced fat)
mediterranean with supplemented extra virgin olive oil 
mediterranean with supplemented mixed nuts

The main finding was that the incidence of a major cardiovascular event was lower among people who followed mediterranean diet with supplemented virgin olive oil and mixed nuts.

What were the results of the PREDIMED study on diabetes risk?

Both mediteranian diet groups (with olive oil and with nuts) had a lower diabetes incidence after 5 years compared to control (low fat diet).
Increased adherence to mediterranean diet with olive oil or with nuts decreased the incidence of t2d

What are the results of the PREDIMED study on diabetic retinophaty and diabetic nefropathy?

Retinopathy: mediterranean diet of olive oil and of nuts may protect to retinopathy compared to control
Nephropathy: Mediterranean diet did not protect compare to control

What are the 4 key points of the EASD 2019 guidelines for lifestyle for prevention of CVD for people with diabetes?

- lifestyle changes are key to prevent DM and its CV complications
- reduced calorie intake is recommened to lower excessive body weight in patients with DM
- a mediterranean diet supplemented with olive oil and/or nuts reduces the incidence of major CV events
- moderate-to-vigorous physical activity of >150 min/week is recommended for the prevention and control of DM

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